What is CBD?

Cannabidiol, also known as CBD, is one of over 60+ naturally occurring cannabinoid compounds found in cannabis, an annual herbaceous flowering plant. "Cannabis" is a general umbrella term used to cover both marijuana and hemp plants. Our CBD products and extracts are derived from hemp rather than marijuana.

Unlike THC, a well-known and studied cannabinoid frequently found in marijuana, CBD does not have psychoactive effects. You will not get “high” from CBD, which is part of the reason why it is legal in most parts of the world.

How does it work?

CBD primarily interacts with the body’s endocannabinoid system.


Almost every organ in your body contains cannabinoid receptors that react to naturally occurring cannabinoids produced in your body, known as endocannabinoids. CBD is a plant-based cannabinoid, called a phytocannabinoid.


The endocannabinoid system has four primary purposes:

  1. Neuroprotection
  2. Stress relief
  3. Immune response
  4. Regulating the body’s general state of balance


Unlike THC, CBD does not interact directly with the two cannabinoid receptors CB1 and CB2. This is why CBD does not cause any psychoactive effects. Instead, CBD activates other receptors, like the vanilloid, adenosine and serotonin receptors.

What receptors can CBD affect?

By activating the TRPV-1 receptor, cannabidiol plays a role in the mediation of body temperature, pain perception and inflammation


CBD inhibits the FAAH enzyme, a compound that activates the CB1 receptor. By doing so, CBD minimizes the activation of CB1 by THC, reducing its psychoactive effects.


The activation of adenosine receptors by CBD gives the anti-anxiety and anti-inflammatory effects of cannabidiol. Adenosine receptors are also involved in the release of dopamine and glutamate, two neurotransmitters that play major roles inside the body. Dopamine is involved in cognition, motor control, motivation and reward mechanisms, while glutamate is one of the major mediators of excitatory signals, being involved in memory, learning and cognition.


High concentrations of CBD have been shown to activate the 5-HT1A serotonin receptor, exerting anti-depressant effects. The same receptor is involved in a series of processes from pain perception, appetite, nausea and anxiety to sleep and addiction mechanisms.


Finally, CBD blocks CPR55 signaling, decreasing bone re-absorption and cancer cell proliferation. GPR55 is widely present inside the brain, being linked with the modulation of bone density and blood pressure, as well as with cancer cell proliferation.

Amberley Calvo - Elixinol, 2015

What conditions can CBD help with?

CBD has been proven to be extremely beneficial in treating hundreds of illnesses. We have compiled a short list below, but there are countless others. Hemp truly is a miraculous plant!

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References

Bluebird Botanicals. (2018). What is CBD oil & how does it work? Hemp & CBD FAQs

Retrieved from https://bluebirdbotanicals.com/hemp-cbd-oil-faq/


Calvo, A. (2015). How Does Cannabidiol (CBD) Work? Elixinol

Retrieved from https://elixinol.com/blog/how-does-cannabidiol-cbd-work/